In vivo reference point indentation measurement variability in skeletally mature inbred mice

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In vivo reference point indentation measurement variability in skeletally mature inbred mice.

Reference point indentation (RPI) was developed to measure material-level mechanical properties of bone in vivo. Studies using RPI in vivo have discriminated between human subjects with previous skeletal fractures and those without and among dogs given different anti-remodeling drugs. Recently, this technology was extended to rats, providing the first in vivo data for rodents. The goal of the p...

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Reference point indentation (RPI) has emerged as a novel tool to measure material-level biomechanical properties in vivo. Human studies have been able to differentiate fracture versus non-fracture patients while a dog study has shown the technique can differentiate drug treatment effects. The goal of this study was to extend this technology to the in vivo measurement of rats, one of the most co...

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ژورنال

عنوان ژورنال: BoneKEy Reports

سال: 2015

ISSN: 2047-6396

DOI: 10.1038/bonekey.2015.81